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重组人血管内皮生长因子受体-2/Fc嵌合体（sKDR-Fc, D7, Sf9）

sVEGFR-2 (sKDR-Fc, D7),human, recombinant (Sf9), 10 μg

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Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signalling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin. |Recombinant human soluble Vascular Endothelial Growth Factor Receptor-2 (sVEGFR2D1-7) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-2D1-7/Fc is a disulfide-linked homodimeric protein.
Formulation: Lyophilized in PBS (pH 7.4)
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货号 名称 单位 购买
C-64472 重组人血管内皮生长因子受体-2/Fc嵌合体（sKDR-Fc, D7, Sf9） 10 μg/管 商城订购
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