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重组人血管内皮生长因子受体2(sKDR,native;InC)

sVEGFR-2 (sKDR, native),human, recombinant (InC), 5 μg

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详细描述:
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR -1 (Flt-1), VEGFR -2 (KDR/Flk-1), VEGFR -3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR -1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR -2 has a lower affinity for VEGF than the Flt -1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR -2 leading to their proliferation. The binding of VEGF165 to VEGFR-2 is dependent on heparin. Recombinant Human soluble Vascular Endothelial Growth Factor Receptor 2 (sKDR) generated by alternative splicing consist of the first 6 Ig-like loops followed by the unique C-terminal end: CGRETILDHSAEAVGMP. It contains 659 amino acids and has a molecular weight of 105 kDa (monomer).
Formulation:Lyophilized from a sterile-filtered protein solution in 25 mM MES, 100 mM NaCl (pH 5.5).
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-64469 重组人血管内皮生长因子受体2(sKDR,native;InC) 5 μg/管 商城订购
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