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重组人肾母细胞瘤过表达基因

NOV, human, recombinant, 20 μg

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详细描述：
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa non glycosylated, single polypeptide chain consisting of 331 amino acid residues and purified using proprietary chromatographic techniques.
Formulation:Lyophilized from a sterile-filtered (0.2 µm filter), concentrated protein solution in 20 mM TrisHCl (pH 8.6) and 150 mM NaCl.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-64335 重组人肾母细胞瘤过表达基因 20 μg/管 商城订购
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