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重组人基质金属蛋白酶7

MMP-7, human, recombinant, 20 μg

产品概述 技术指标 配套产品 订购信息 精彩视频 相关资料
详细描述：
Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. It is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain lacking the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9, but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas.Recombinant human MMP-7 produced in E. coli is a single, non-glycosylated polypeptide chain having a molecular mass of 19.13 kDa. It has been purified by using proprietary chromatographic techniques.
Formulation: Sterile clear liquid solution containing 10 mM HEPES (pH 7.4), 5 mM CaCl2 and 150 mM NaCl.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-64110 重组人基质金属蛋白酶7 20 μg/管 商城订购
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