详细描述：
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by upregulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant human MMP-1 is a 45 kDa single, nonglycosylated polypeptide chain consisting of 393 amino acids (aa 100-469) fused to a 23 amino acid His-tag at the N-terminus.
Formulation: Sterile-filtered, colorless protein solution (1 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4 M urea.
