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重组人胸腺基质淋巴细胞生成素(TSLP)

TSLP, human, recombinant, 10 μg

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详细描述:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7RɲͿand the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)- derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFɲͿwhile down-regulating IL-10 and IFN-ɶsuggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa single, non-glycosylated polypeptide chain consisting of 132 amino acid residues. It has been purified using proprietary chromatographic techniques.
Formulation: Lyophilized from a sterile-filtered (0.2 µm filter), concentrated (1 mg/ml) protein solution in 20 mM sodium phosphate (pH 7.4) and 130 mM NaCl.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-63770 重组人胸腺基质淋巴细胞生成素(TSLP) 10 μg/管 商城订购
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