info_wh@genecompany.com| 基因科技武汉|

当前位置：首页 > 产品中心

产品中心

技术交流

扫描二维码
或添加“GeneGroup003”
获取更多更新资讯

商城订购

扫描二维码
或添加“基因商城（GeneMart）”
手机下单，快人一步

售后服务

扫描二维码
或添加“GeneGroup005”
获取更快速售后支持

重组人肿瘤坏死因子受体融合蛋白（CHO）

TNF-Receptor Fusion Protein,human, recombinant (CHO), 50 μg

产品概述 技术指标 配套产品 订购信息 精彩视频 相关资料
详细描述：
TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA) and ankylosing spondylitis. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS) and plaque psoriasis. Recombinant TNFR inhibits the activity of TNF in vitro and has been shown to affect several animal models of inflammation, including murine collageninduced arthritis. It inhibits binding of both TNF-α and TNF-β (lymphotoxin alpha [LTα]) to cell surface TNFRs, rendering TNF biologically inactive. Cells expressing transmembrane TNF that bind to TNFR are not lysed in vitro in the presence or absence of complement. rTNFR can also modulate biological responses that are induced or regulated by TNF, including expression of adhesion molecules responsible for leukocyte migration (i.e., E-selectin and to a lesser extent intercellular adhesion molecule-1 [ICAM-1]), serum levels of cytokines (e.g., IL-6) and serum levels of matrix metalloproteinase-3 (MMP-3 or stromelysin).|Human TNFR produced in CHO is a dimeric, glycosylated polypeptide chain consisting of the extracellular ligand-binding portion of the human 75 kDa (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of TNFR contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kDa.
Formulation: Sterile-filtered, white, lyophilized (freeze-dried) powder. Each mg contains 1.6 µg mannitol, 0.4µg sucrose and 48 µg tromethamine.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-63726 重组人肿瘤坏死因子受体融合蛋白（CHO） 50 μg/管 商城订购
    彩页：
    操作指南：
    相关文献：

新闻促销活动

相关产品

获得帮助

本网页所展示产品仅限于科研用途，产品信息可能存在更新滞后的情况，请一切以厂家官方说明及实物为准。 仅供科研使用。不可用于诊断或治疗。

欢迎关注我司“基因快讯”与“基因售后服务”官方微信

仪器报修 试剂售后 配套耗材/试剂订购 技术支持
法律声明 隐私政策
售后服务 订购指南

未经书面授权，所有页面内容、图片和设计不得以任何形式进行复制
Copyright © 2025 genecompany,All Rights Reserved
武汉市东湖新技术开发区高新大道666号生物产业（九峰）创新基地B13栋3楼 电话：027-87166462

鄂公网安备42018502006300

 鄂ICP备2022001168号-1