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重组人可溶性肿瘤坏死因子受体1型（CD120a）

sTNF-R1 (CD120a), human,recombinant, 20 μg

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详细描述：
TNFR1 belongs to the TNF-receptor superfamily and is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR1 and sTNFR2, which act to neutralize the biological activities of TNF-alpha and TNF-beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors.TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury. TNFR1 is capable of signaling both cell survival and apoptosis. It is capable of activating NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 contributes to the induction of noncytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Human TNFR1 has a major region which controls cell surface expression. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women. Germline mutations of the extracellular domains of TNFR1 are linked to the autosomal dominant periodic fever syndrome. The impaired receptor clearance is believed to be a mechanism of the disease. Familial hibernian fever (FHF) is caused by defects in TNFRSF1A gene. Human Recombinant TNFR1 produced in E. coli is a single, non-glycosylated, polypeptide chain of 162 amino acids, having a total molecular mass of 18.2 kDa. Human recombinant TNFR1 has been purified using proprietary chromatographic techniques.
Formulation: The TNFR protein was lyophilized from a 10 mM sodium phosphate buffer (pH 7.5).
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C-63725 重组人可溶性肿瘤坏死因子受体1型（CD120a） 20 μg/管 商城订购
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