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重组人TGF-β2

TGF-betaR2, human, recombinant, 10 μg

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详细描述：
TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer. Human Recombinant TGFBR2 produced in E. coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids (27-159 aa, the extracellular domain of TGFBR2) with a molecularmass of 15.1 kDa.
Formulation: Lyophilized from a 0.2 µm sterile-filtered solution in buffer containing 150 mM NaCl and 50 mM sodium phosphate buffer (pH 7.5).
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货号 名称 单位 购买
C-63540 重组人TGF-β2 10 μg/管 商城订购
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