详细描述：
The three mammalian forms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation, and motility as well as syntehsis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling, and wound healing, and are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
