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重组人同种异体移植炎性因子1

AIF-1, human, recombinant, 10 μg

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详细描述：
AIF-1 is expressed in macrophages and neutrophils. The expression of AIF-1 transcripts is upregulated by IFN-g in rat macrophages. AIF-1 is expressed selectively in human macrophagelike cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. In quiescent cultured human vascular smooth muscle cells synthesis of AIF-1 is induced by IFN-g, IL-1b, and conditioned medium of T-cells. Overexpression of AIF-1 in human VSMCs results in enhanced growth of these cells. AIF-1 is expressed during apoptosis rat mammary gland and ventral prostate tissues. Allograft Inflammatory Factor 1 is expressed by several tumor-associated activated macrophages and microglial cells in rat and human gliomas. There is an evident relationship of AIF1-expressing activated macrophages and microglial cells with tumor malignancy in humans. Human AIF-1 protein shares 98% homology/identity with that of rat. Recombinant human AIF-1 contains a total of 155 amino acids and has a molecular Mass of 17.7 kDa. The human AIF-1 is fused to a 9 amino acid long N-terminal His tag.
Formulation: Sterile filtered and lyophilized from a 0.5 mg/ml protein solution in 20 mM Tris buffer and 50 mM NaCl (pH 7.5).
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C-63412 重组人同种异体移植炎性因子1 10 μg/管 商城订购
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