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重组人可溶性IL-2受体α(CD25,TAC抗原;InC)

sIL-2R alpha (CD25), human, recombinant (InC), 10 μg

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详细描述:
The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R alpha, IL-2R beta, and IL-2R gamma. The IL-2R alpha is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a.intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R alpha releases the entire extracellular domain of IL-2R alpha thereby generating a 219 a.a. soluble protein called soluble IL-2R alpha (sIL-2R alpha). The homodimeric form binds IL-2 (KD=10 mM) and facilitates IL-2 signaling. The secreted sIL-2R alpha is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R alpha produced in Sf9 cells is a single, glycosylated polypeptide chain of 461 amino acids (22-240 a.a.), having a molecular mass of 52.1 kDa (molecular size on SDSPAGE will appear at approximately 50-70 Da).
Formulation: Sterile-filtered (0.2 micron filter), colorless protein solution (0.5 mg/ml) in phosphate buffered saline (pH 7.4) and 10% glycerol.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-63334 重组人可溶性IL-2受体α(CD25,TAC抗原;InC) 10 μg/管 商城订购
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