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重组人色素上皮衍生因子(HEK)

PEDF, human, recombinant (HEK), 10 μg

产品概述 技术指标 配套产品 订购信息 精彩视频 相关资料
详细描述:
PEDF is a neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Aqueous humour level of asymmetric dimethylarginine is correlated with PEDF in humans. ADMA and PEDF levels are increased in response to inflammation in uveitis. Lack of PEDF expression is a potent factor for the enhancement of tumor growth and angiogenesis in breast cancer. PEDF & VEGF genes contribute to the development of diabetic retinopathy. PEDF and VEGF structural changes in blood vessel wall play an important role in the pathophysiology of PD patients. PEDF-overexpressing tumors exhibited reduced intratumoral angiogenesis. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy. VEGF secreted by retinal pigment epithelial cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. Sentrin-F1 concentration in the aqueous humor of diabetic patients predicts who will develop progression of retinopathy. PEDF blocks angiogenic effects of leptin through its anti-oxidative properties. Human recombinant PEDF produced in HEK cells is a single, glycosylated, polypeptide chain containing 410 amino acids and having a molecular mass of 45.6 kDa. The Human Sentrin-F1 is fused to FLAG tag at N-Terminus.
Formulation: The filtered concentrated (0.5 mg/ml) protein solution was lyophilized against 20 mM Tris and 20 mM NaCl (pH 7.5).
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-63031 重组人色素上皮衍生因子(HEK) 10 μg/管 商城订购
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