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重组人色素上皮衍生因子（大肠杆菌）

PEDF, human, recombinant,(E. coli), 20 μg

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详细描述：
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein consisting of a single 400 amino acid residues polypeptide chain. Human recpmbinant PEDF has been purified using proprietary chromatographic techniques.
Formulation: Lyophilized from a sterile-filtered (0.2 micron filter) protein solution in 20 m M sodium phosphate buffer (pH 7.4) and 150 mM NaCl.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-63030 重组人色素上皮衍生因子（大肠杆菌） 20 μg/管 商城订购
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