详细描述：
Human IL-36a (IL-36A) belongs to the IL-1 family which includes IL-1b, IL-1a, IL-1RA, IL-18, IL-36RA (IL-1F5), IL-36b (IL-1F8), IL-36g (IL-1F9), IL-37 (IL-1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. IL-36a is an 18-22 kDa, 158 aa intracellular and secreted protein which holds no signal sequence, no prosegment and no potential from N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Human IL-36a (aa 6-158) shares 57-68% aa sequence homology with mouse, rabbit, equine and bovine IL-36a, and 27-57% aa sequence homology with other new IL-1 family members. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. Human recombinant IL-36 alpha produced in E. coli is a single, non-glycosylated, polypeptide chain of 153 amino acids (aa 6-158) with a molecular mass of 17.0 kDa. The recombinant IL-36A has been purified using proprietary chromatographic techniques
Formulation: White (freeze-dried) powder. Lyophilized from a sterile-filtered (0.2 µm) protein solution in 20 mM Tris-HCl, 150 mM NaCl, 0.1% Tween 20 (pH 8.0).
