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重组人白细胞介素17A(大肠杆菌)

IL-17, human, recombinant,(E. coli), 25 μg

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详细描述:
IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As interleukin-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. Interleukin-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. Recombinant human IL-17 produced in E. coli is a homodimeric, non-glycosylated polypeptide chain containing of 264 amino acids and a molecular mass of 30,250 Dalton.
Formulation: Sterile-filtered white, lyophilized (freeze-dried) powder. Lyophilized from a concentrated (1 mg/ml) protein solution in 20 mM citrate, 0.1 M NaCl (pH 4.5).
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-62710 重组人白细胞介素17A(大肠杆菌) 25 μg/管 商城订购
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