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重组人白细胞介素13(变异体)

IL-13 (variant), human,recombinant, 10 μg

产品概述 技术指标 配套产品 订购信息 精彩视频 相关资料
详细描述:
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1ɴ͕TNF-ɲ͕IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PromoCell's genetic variant, termed human IL-13 analog, is mature 12.5 kDa protein (single, non-glycosylated polypeptide chain of 114 amino acids) with a substitution of Q for R at position 112 compared with the wild type IL-13. It has been purified using proprietary chromatographic techniques.
Formulation: Lyophilized from a sterile-filtered (0.2 µm filter), concentrated protein solution in 1XPBS (pH 7.2) containing 5% trehalose.
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货号 名称 单位 购买
C-62314 重组人白细胞介素13(变异体) 10 μg/管 商城订购
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