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重组人可溶性白细胞介素6受体（CD126）

sIL-6 Receptor (CD126),,human, recombinant (E. coli), 20 μg

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详细描述：
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. The IL-6R alpha chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R alpha. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R alpha alone. IL-6R alpha expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R alpha which consists of only the extracellular domain of the IL-6R alpha chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R produced in E. coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (20-357) corresponding to the mature IL-6R protein with a molecular weight of 42.25 kDa and an aminoterminal hexahistidine tag. The sIL6R is purified by proprietary chromatographic techniques.
Formulation:Sterile-filtered, clear solution (0.18 mg/ml). CD126 His-tag protein is supplied in 20 mM Tris-HCl, pH 8.0, 0.8 M Urea and 50% glycerol.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-61631 重组人可溶性白细胞介素6受体（CD126） 20 μg/管 商城订购
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