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重组人白细胞介素-1受体拮抗剂

IL-1 RA, human, recombinant, 100 μg

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详细描述：
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the IL-1 family. Endogenous IL-1 RA is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. IL-1 RA is a naturally occurring protein which inhibits the activity of IL-1- alpha and IL-1-beta by competitively blocking binding to their type I and type II receptors. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL-1-beta on the production of soluble and intracellular forms of IL-1 RA. The regulated expression of IL-1 RA in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1 RA is markedly enhanced by IL-1, TNF-alpha or PDGF. Recombinant human IL-1 RA produced in E. coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17,000 Dalton.
Formulation:Lyophilized from a sterile-filtered protein solution with no additives.
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货号 名称 单位 购买
C-61122 重组人白细胞介素-1受体拮抗剂 100 μg/管 商城订购
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