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重组人胰岛素样生长因子结合蛋白7

IGF-BP7, human, recombinant, 25 μg

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详细描述:
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4 kDa non-glycosylated, homodimeric protein consisting of 2 x 256 amino acid residues.
Formulation:Lyophilized from a sterile-filtered (0.2 µm filter), concentrated protein solution in 20 mM TrisHCl (pH 8.5) and 150 mM NaCl.
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-60855 重组人胰岛素样生长因子结合蛋白7 25 μg/管 商城订购
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