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重组人胰岛素样生长因子结合蛋白-3

IGF-BP3, human, recombinant, 25 μg

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详细描述：
Insulin Like Growth Factor Binding Protein-3 is one of the six homologous proteins that specifically bind insulin-like growth factors and modulate their mitogenic and metabolic actions. IGFBP-3 is the major IGF binding protein present in serum of humans and animals. It is also present in the alpha granules of platelets. IGFBP-3 shows a similar affinity for IGF-1 and IGF-2. IGF-BP-3 inhibits follicle stimulating hormone. Markedly decreased levels of IGF-BP-3 are observed in patients with Growth hormone deficiencies, while markedly elevated levels are observed in patients with high levels of Growth hormone (acromegaly). In murine fibroblasts the synthesis of IGFBP-3 is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. In human skin fibroblasts the synthesis of IGFBP-3 is stimulated by TGF-beta. Recombinant human IGFBP-3 produced in E. coli is a single, non-glycosylated polypeptide chain of 264 amino acids and a molecular mass of 28,806 Dalton.
Formulation:White, lyophilized (freeze-dried) powder. IGFBP-3 was lyophilized from a sterile-filtered (0.2 µm filter), concentrated (0.5 mg/ml) protein solution with 20 mM HCl.
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C-60848 重组人胰岛素样生长因子结合蛋白-3 25 μg/管 商城订购
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