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重组人干扰素调节因子3

IRF-3, human, recombinant, 20 μg

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详细描述：
Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization , nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the ie and prdiii regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains. Human recombinant IRF-3 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids (1-112) and having a molecular mass of 13 kDa.
Formulation:Sterile-filtered, colorless protein solution (1 mg/ml) in 1X PBS (pH 7.4).
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-60606 重组人干扰素调节因子3 20 μg/管 商城订购
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