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重组人可溶性成纤维细胞生长因子受体1a(IIIc)/Fc嵌合体(CHO)

FGFR-1/Fc, human,recombinant (CHO), 50 μg

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详细描述:
The FGF family plays a central role during prenatal development and postnatal growth, and theregeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous multiple forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant human FGFR-1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel.
Formulation:Sterile-filtered, white, lyophilized (freeze-dried) powder. The protein was lyophilized from a sterile-filtered (0.2 micron) protein solution in 10 mM sodium phosphate (pH 7.5).
货号 产品名称 品牌 购买
货号 名称 单位 购买
C-60454 重组人可溶性成纤维细胞生长因子受体1a(IIIc)/Fc嵌合体(CHO) 50 μg/管 商城订购
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